Melanoma brain metastasis
Data description
Descriptive characteristics of the selected melanoma brain metastasis studies.
| MBM-1 | MBM-2 | MBM-3 | |
|---|---|---|---|
| Organism | human | human | human |
| Data type | RNA-seq | snRNA-seq | RNA-seq |
| Sample type | microdissected FFPE tumors | fresh frozen surgical resections | microdissected FFPE tumors |
| Comparison | MBM vs MNBM | MBM vs MNBM | MBM vs non tumor-bearing brain controls |
| Results availability | all genes | all genes | significant genes |
| Number of upregulated genes | 418 | 7201 | 685 |
| Number of downregulated genes | 568 | 9377 | 431 |
| Reference | PMID: 30787016 | PMID: 35803246 | PMID: 36435874 |
MBM: melanoma brain metastasis; MNBM: melanoma non-brain metastasis; FFPE: Formalin-Fixed Paraffin-Embedded.
Differential gene expression results
Explore the differential gene expression results downloaded from the selected studies.
Results obtained from the publication Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
Comparison: brain melanoma metastatic cells vs melanoma metastatic cells from other locations.
Summary
| Study ID | Total genes evaluated | Significative genes | Significative genes upregulated | Significative genes downregulated |
|---|---|---|---|---|
| MBM-1 | 10000 | 986 | 418 | 568 |
Of note, upregulated genes are those with a positive logFC value (logFC > 0); meaning that they are more expressed in the brain melanoma metastatic cells. Downregulated genes are those with negative logFC value (logFC < 0); meaning that they are more expressed extracranial melanoma metastatic cells.
Results at gene level
Results obtained from the publication Dissecting the treatment-naive ecosystem of human melanoma brain metastasis
Comparison: brain melanoma metastatic cells vs melanoma metastatic cells from other locations.
Summary
| Study ID | Total genes evaluated | Significative genes | Significative genes upregulated | Significative genes downregulated |
|---|---|---|---|---|
| MBM-2 | 35638 | 16578 | 7201 | 9377 |
Of note, upregulated genes are those with a positive logFC value (logFC > 0); meaning that they are more expressed in the brain melanoma metastatic cells. Downregulated genes are those with negative logFC value (logFC < 0); meaning that they are more expressed extracranial melanoma metastatic cells.
Results at gene level
Results obtained from the publication Decoding molecular programs in melanoma brain metastases
Comparison: brain melanoma metastatic cells vs non tumor-bearing brain controls.
Summary
| Study ID | Total genes evaluated | Significative genes | Significative genes upregulated | Significative genes downregulated |
|---|---|---|---|---|
| MBM-3 | not known | 1116 | 685 | 431 |
Of note, upregulated genes are those with a positive logFC value (logFC > 0); meaning that they are more expressed in the brain melanoma metastatic cells. Downregulated genes are those with negative logFC value (logFC < 0); meaning that they are more expressed control condition.
Results at gene level