Neurodegenerative signature

Key concepts

Assessed comparisons:

MBM-3: melanoma metastatic cells in the brain compared to non tumor-bearing brain controls.
AD-CT: cortex brain region from Alzheimer’s disease patients compared to cortex brain region from controls.
AD-HP: hippocampus brain region from Alzheimer’s disease patients compared to hippocampus brain region from controls.
PD-SN: substantia nigra brain region from Parkinson’s disease patients compared to substantia nigra brain region from controls.
PD-ST: striatum brain region from Parkinson’s disease patients compared to striatum brain region from controls.
MS: brain samples from multiple sclerosis patients compared to brain samples from controls.

Evaluation of the transcription pattern change in significant genes of each comparison:

Upregulated genes (UP, logFC > 0): genes more expressed in the first condition of the comparison (i.e. melanoma metastatic cells in the brain for MBM-3, or case samples for the neurodegenerative meta-analyses).
Downregulated genes (DOWN, logFC > 0): genes more expressed in the second condition of the comparison (i.e. non tumor-bearing brain controls for MBM-3, or control samples for the neurodegenerative meta-analyses).

Gene dysregulation profile by study/meta-analysis of the neurodegenerative signature:

Gene dysregulation profile by study/meta-analysis of the melanoma brain-specific metastasis genes (MBM-3).