Transcription Factor Activity

The analysis was conducted on the basis of meta-analysis results from the cerebral cortex region. Comparisons assessed:

IDF: impact of Alzheimer’s disease in females (case female - control female).
IDM: impact of Alzheimer’s disease in males (case male - control male).
SDID: sex-based differential impact on Alzheimer’s disease [(case female - control female) - (case male - control male)].

Transcription factors with significantly altered activity in SDID comparison

Activation values are measured as normalized enrichment scores (NES). Transcription factors labeled as “Activated” display positive values of NES in all comparisons, “Repressed” display negative values of NES in all comparisons, and “Divergent” display qualitative differences in their activation across the IDF, IDM, and SDID comparisons.

Results at transcription factor level

NES: normalized enrichment scores; Size: number of target genes.

Of note, upregulated genes are those with a positive logFC value (logFC > 0); meaning that they are more expressed in Alzheimer’s disease females. Downregulated genes are those with negative logFC value (logFC < 0); meaning that they are more expressed in control females.

NES: normalized enrichment scores; Size: number of target genes.

Of note, upregulated genes are those with a positive logFC value (logFC > 0); meaning that they are more expressed in Alzheimer’s disease males. Downregulated genes are those with negative logFC value (logFC < 0); meaning that they are more expressed in control males.

NES: normalized enrichment scores; Size: number of target genes.

Of note, upregulated genes are those with a positive logFC value (logFC > 0); meaning that they are more expressed in Alzheimer’s disease females compared to males. Downregulated genes are those with negative logFC value (logFC < 0); meaning that they are more expressed in Alzheimer’s disease males compared to females.