| Meta-analysis region | Comparison | Total genes evaluated | Total significative genes | Significative genes upregulated | Significative genes downregulated |
|---|---|---|---|---|---|
| Cortex | IDF | 36767 | 3763 | 1788 | 1975 |
| Hippocampus | IDF | 22880 | 201 | 148 | 53 |
| Cortex | IDM | 36767 | 1876 | 918 | 958 |
| Hippocampus | IDM | 22880 | 16 | 9 | 7 |
| Cortex | SDID | 36767 | 389 | 140 | 249 |
| Hippocampus | SDID | 22880 | 0 | 0 | 0 |
Meta-analyses results
Summary
Comparisons of cortex / hippocampus samples:
IDF: impact of Alzheimer’s disease in females (case female - control female).
IDM: impact of Alzheimer’s disease in males (case male - control male).
SDID: sex-based differential impact on Alzheimer’s disease [(case female - control female) - (case male - control male)].
Of note, upregulated genes are those with a positive logFC value (logFC > 0); meaning that they are more expressed in the first condition of the comparison: for IDF and IDM, Alzheimer’s disease condition; for SDID Alzheimer’s disease females compared to males.
Downregulated genes are those with negative logFC value (logFC < 0); meaning that they are more expressed second condition of the comparison: for IDF and IDM, control condition; for SDID Alzheimer’s disease males compared to females.
Results at gene level
Number of studies: number of studies where the gene is evaluated; CI: confidence interval