Protein-Protein Interaction Networks subset I

This functional characterisation has been carried out for the 179 significant genes of the “More repressed genes in Alzheimer’s disease females” subset (Subset I from the research article). They are genes downregulated in the SDID comparison (logFC < 0), meaning that are repressed in Alzheimer’s disease females compared to males; and downregulated in the IDF comparison (logFC < 0), meaning that are represesed in Alzheimer’s disease females compared to control females.

Network visualization

Protein-Protein Interaction network of more repressed genes in Alzheimer’s disease females. Only network edges with an interaction score greater than 0.7 are shown. Network nodes are colored according to their cluster

 

Functional characterization by cluster

Genes: CACNG3, CAMK2A, DLG3, GLRB, LRRC7, MEF2C, NBEA, NEDD4L.

Strength: Log10(observed / expected)

Genes: ATP6AP2, ATP6V1A, ATP6V1B2, ATP6V1C1, ATP6V1D, SEH1L, SLBP.

Strength: Log10(observed / expected)

Genes: ARL8B, FKBP1B, HOMER1, ITPR1, PPP3CB, PPP3R1, PRKCB.

[Strength: Log10(observed / expected)]{style=“color: #999999”, fig-align=“center”}

Genes: AMPH, EFNB3, NECAP1, PNMA2, SH3GL2, VPS35.

Strength: Log10(observed / expected)

Genes: MADD, MAP2K1, MAP2K4, PPP2R5D.

Strength: Log10(observed / expected)

Genes: ARHGEF9, GABRA1, GABRA5, GABRG2.

Strength: Log10(observed / expected)

Genes: CDC37L1, DNAJA2, DNAJA4, HSP90AB1.

Strength: Log10(observed / expected)

Genes: NCAM2, NRCAM, PRNP, SCN4B.

Strength: Log10(observed / expected)

Genes: COPS8, DCAF6, TESPA1.

Strength: Log10(observed / expected)

Genes: UBE2E2, UBE2T, UBE2W.

Strength: Log10(observed / expected)

Total evaluated genes: AACS, AASDHPPT, ACAD8, ADAM23, AMPH, ANO3, ARHGEF9, ARL8B, ATP6AP2, ATP6V1A, ATP6V1B2, ATP6V1C1, ATP6V1D, B4GALT6, BBS7, BEND6, BNIP3, BTBD10, BTRC, C11orf87, CAB39, CACNG3, CADPS, CALB1, CALY, CAMK1G, CAMK2A, CBLN2, CCDC3, CCDC6, CDC37L1, CDH12, CELSR2, COPS8, CPNE4, DCAF6, DLG3, DNAJA2, DNAJA4, EBP, EFNB3, EIF2S3, EIF4E3, ELMOD1, EPB41L3, EPDR1, FABP3, FAXC, FBXL16, FBXO28, FBXO33, FBXO34, FKBP1B, FRMPD4, GABRA1, GABRA5, GABRG2, GHITM, GLRB, GOT1, GPR137C, GPR22, GPRASP2, HLF, HOMER1, HSP90AB1, HTR1E, INA, INSIG2, ITPR1, JAZF1, KCND2, KCNJ6, KCNV1, KIF3C, KIFAP3, KLHL2, KLK7, KRT222, LAMP5, LGMN, LMBR1, LNX1, LOC441488, LRRC2, LRRC7, LRRC8B, LZTFL1, MADD, MAL2, MAP2, MAP2K1, MAP2K4, MAST3, MEF2C, MGST3, MMD, MPP1, MRAP2, MYH10, MYO5A, NBEA, NCAM2, NCDN, NCKAP1, NECAB1, NECAP1, NEDD4L, NETO2, NIPSNAP3B, NKRF, NLK, NRCAM, PACSIN1, PCMT1, PCSK2, PHF14, PIP4K2C, PLXNA2, PNMA1, PNMA2, PPM1E, PPP2R5D, PPP3CB, PPP3R1, PRICKLE2, PRKCB, PRNP, PRPS2, PRSS3, PTPRT, RAB39B, REEP1, REEP5, RGS4, RIC3, RIMS3, RSPO2, SCN4B, SEC23A, SEH1L, SELT, SEMA4F, SH3BGRL2, SH3GL2, SLBP, SLC30A3, SLITRK3, SLITRK4, SLITRK5, SNX10, SPATA2, SSX2IP, ST6GALNAC5, STAMBPL1, STEAP2, STK26, STMN3, SUSD4, TBC1D9, TBPL1, TBR1, TCERG1L, TERF2, TESPA1, THY1, TOLLIP, TOMM34, TUSC3, UBE2E2, UBE2T, UBE2W, UQCRC2, VPS35, VSNL1, VSTM2L, VTA1, ZNF189, ZNF385B.

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