GSE15222

Exploratory analysis

Select the exploratory analysis of interest by clicking on the tab.

CT: cortex

Due to the large number of samples, the boxplots of the first 50 samples are shown. The distribution of counts is uniformly consistent across all samples.

 

Differential gene expression analysis

Comparisons of cortex brain samples:

  • IDF: impact of Alzheimer’s disease in females (case female - control female).

  • IDM: impact of Alzheimer’s disease in males (case male - control male).

  • SDID: sex-based differential impact on Alzheimer’s disease [(case female - control female) - (case male - control male)].

Summary

 

Study ID Comparison Total genes evaluated Significative genes Significative genes upregulated Significative genes downregulated
GSE15222 IDF 16742 8741 5042 3699
GSE15222 IDM 16742 3682 2054 1628
GSE15222 SDID 16742 415 267 148

Of note, upregulated genes are those with a positive logFC value (logFC > 0); meaning that they are more expressed in the first condition of the comparison: for IDF and IDM, Alzheimer’s disease condition; for SDID Alzheimer’s disease females compared to males.

Downregulated genes are those with negative logFC value (logFC < 0); meaning that they are more expressed second condition of the comparison: for IDF and IDM, control condition; for SDID Alzheimer’s disease males compared to females.

 

Results at gene level

 

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