General Options
| Organisms | Human | ||
| WT mice | |||
| TLR4-KO mice | |||
| Performed Contrasts | Alias | Comparison | |
| EEF comparison | Ethanol vs. Control in Females | ||
| EEM comparison | Ethanol vs. Control in Males | ||
| SEI comparison | (Ethanol vs. Control in Females) vs. (Ethanol vs. Control in Males) | ||
| Number of lipids | Ion mode | Organism | N |
| Negative | Human | 330 | |
| Positive | Human | 247 | |
| Negative | WT mice | 291 | |
| Positive | WT mice | 264 | |
| Negative | TLR4-KO mice | 291 | |
| Positive | TLR4-KO mice | 264 | |
|
Sample Class Summary
| Organism | Ion mode | Alcohol | Control | Total | ||
|---|---|---|---|---|---|---|
| Female | Male | Female | Male | |||
| Human | Negative | 9 | 9 | 9 | 9 | 36 |
| Positive | 9 | 8 | 9 | 9 | 35 | |
| WT mice | Negative | 6 | 6 | 6 | 5 | 23 |
| Positive | 6 | 6 | 6 | 6 | 24 | |
| TLR4-KO mice | Negative | 6 | 6 | 6 | 6 | 24 |
| Positive | 6 | 6 | 6 | 6 | 24 | |
Differential Abundance Summary
| Organism | Ion mode | EEF comparison | EEM comparison | SEI comparison | Total Lipids | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Significant | LFC > 0 | LFC < 0 | Significant | LFC > 0 | LFC < 0 | Significant | LFC > 0 | LFC < 0 | |||
| Human | Negative | 51 | 26 | 25 | 13 | 9 | 4 | 22 | 9 | 13 | 330 |
| Positive | 21 | 8 | 13 | 20 | 10 | 10 | 2 | 0 | 2 | 247 | |
| WT mice | Negative | 7 | 5 | 2 | 21 | 14 | 7 | 15 | 10 | 5 | 291 |
| Positive | 5 | 3 | 2 | 26 | 12 | 14 | 5 | 2 | 3 | 264 | |
| TLR4-KO mice | Negative | 63 | 25 | 38 | 22 | 7 | 15 | 1 | 1 | 0 | 291 |
| Positive | 3 | 2 | 1 | 36 | 22 | 14 | 2 | 0 | 2 | 264 | |
Significant lipids are separated according to the sign of their log fold-change (LFC).
In EEF and EEM comparisons, LFC > 0 columns = Differential abundance lipids increased in ethanol conditions; LFC < 0 columns = Differential abundance lipids decreased in ethanol conditions.
In SEI, LFC > 0 columns = Differential abundance lipids increased in females; LFC < 0 columns = Differential abundance lipids increased in males.
| Human | Mice |
|---|---|
|
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Lipid Set Analysis Summary
| Class | Ion mode | EEF comparison | EEM comparison | SEI comparison | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Significant | LOR > 0 | LOR < 0 | Significant | LOR > 0 | LOR < 0 | Significant | LOR > 0 | LOR < 0 | ||
| Super class | Negative | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
| Positive | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Main class | Negative | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
| Positive | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Sub class | Negative | 0 | 0 | 0 | 3 | 2 | 1 | 0 | 0 | 0 |
| Positive | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
Significant lipids are separated according to the sign of their log odds ratio (LOR).
In EEF and EEM comparisons, LOR > 0 columns = This class is enriched in ethanol conditions; LOR < 0 columns = This class is enriched in control conditions.
In SEI, LOR > 0 columns = This class is increased in females; LOR < 0 columns = This class is increased in males.
| Human |
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