Descriptive Analysis Summary

Metaanalysis Options

Contrast Effect Model Functional Profiling Organism
For moderate and severe Injuries:
  • Acute - Control
  • Subacute - Control
  • Early Chronic - Control
  • Late Chronic - Control
 Random Effect Model Gene Set Analysis Rattus norvegicus

Sample Description

Studies Control Moderate injury Severe injury
Acute Subacute Early chronic Late chronic Acute Subacute Early chronic Late chronic
GSE115067 5 - 5 - - 5 - - -
GSE102964 4 - - - 4 - - - -
GSE104317 4 4 4 - - - - - -
GSE93249 3 - - 3 5 - - - -
GSE52763 6 - - - - - 4 8 -
GSE45006 4 8 8 - 4 - - - -
GSE46988 4 - - - - 4 12 - -
GSE29488 3 - - - - 15 9 18 18
GSE2599 3 - - 3 - - - - -
GSE464 17 24 19 9 - 8 7 4 -
VMM 4 - - - - - 8 4 4
Total 57 36 36 15 13 27 45 34 22

Differential Gene Expression Summary

GEO series / Studies Up / Down Regulation Moderate injury Severe injury
Acute vs Control Subacute vs Control Early Chronic vs Chronic Late Chronic vs Chronic Acute vs Control Subacute vs Control Early Chronic vs Chronic Late Chronic vs Chronic
GSE115067 UP - 1799 - - - 916 - -
DOWN - 3242 - - - 1961 - -
GSE102964 UP - - - 1028 - - - -
DOWN - - - 838 - - - -
GSE104317 UP 5288 5101 - - - - - -
DOWN 5556 6094 - - - - - -
GSE93249 UP - - 811 1024 - - - -
DOWN - - 1628 1628 - - - -
GSE52763 UP - - - - - 326 900 -
DOWN - - - - - 72 560 -
GSE45006 UP 4999 3630 - 2747 - - - -
DOWN 5136 4296 - 3157 - - - -
GSE46988 UP - - - - 3928 4927 - -
DOWN - - - - 4890 6330 - -
GSE29488 UP - - - - 4367 3782 4757 3732
DOWN - - - - 5033 5297 6196 5098
GSE2599 UP - - 375 - - - - -
DOWN - - 569 - - - - -
GSE464 UP 589 804 311 - 344 725 532 -
DOWN 364 1100 2301 - 106 637 1068 -
VMM UP - - - - - 8050 7083 7694
DOWN - - - - - 10796 8758 9337

Functional Enrichment Analysis for Moderate Injuries Summary

GEO series / Studies GO KEGG Reactome
Enriched Depleted Total Enriched Depleted Total Enriched Depleted Total
Acute vs Control
GSE464 254 10 264 53 15 68 139 15 154
GSE45006 407 165 572 77 18 95 358 71 429
GSE104317 429 41 470 78 6 84 359 24 383
Subacute vs Control
GSE464 158 81 239 45 20 65 141 31 172
GSE45006 361 159 520 70 22 92 274 106 380
GSE104317 531 71 602 80 13 93 341 41 382
GSE115067 357 87 444 58 17 75 152 60 212
Early chronic vs Control
GSE464 72 51 123 27 6 33 83 24 107
GSE2599 133 58 192 32 21 53 62 66 128
GSE93249 211 15 226 51 13 64 79 35 114
Late chronic vs Control
GSE45006 265 147 412 59 20 79 151 97 248
GSE93249 265 33 298 44 9 53 71 56 127
GSE102964 298 103 401 51 17 68 128 90 218

Functional Enrichment Analysis for Moderate Injuries Summary

GEO series / Studies GO KEGG Reactome
Enriched Depleted Total Enriched Depleted Total Enriched Depleted Total
Early chronic vs control
GSE464 160 31 191 26 21 47 30 27 57
GSE29488 194 42 236 84 5 89 368 23 391
GSE46988 274 181 455 52 33 85 260 70 330
Subacute vs control
GSE464 147 88 235 47 17 64 125 34 159
GSE29488 549 56 605 76 8 84 202 38 240
GSE46988 296 174 470 57 24 81 260 70 330
GSE52763 24 49 73 14 15 29 67 47 114
GSE115067 344 141 485 61 28 89 198 90 288
VBB 373 73 446 68 12 80 214 50 264
Early chronic vs control
GSE464 16 57 73 8 7 15 30 18 48
GSE29488 592 74 666 80 7 87 286 31 317
GSE52763 63 64 127 29 18 47 41 138 179
VBB 335 63 398 67 10 77 133 44 177
Late chronic vs control
GSE29488 564 47 611 73 6 79 195 27 222
VBB 375 67 442 66 9 75 123 43 166

Meta-Analysis Summary

Moderate Injury Severe Injury
Enriched Depleted Total Enriched Depleted Total
Gene Ontology
Acute vs Control 326 40 366 263 49 312
Subacute vs Control 211 51 262 77 25 102
Early Chronic vs Control 99 25 124 51 24 75
Late Chronic vs Control 248 80 328 274 27 301
KEGG
Acute vs Control 70 10 80 56 22 78
Subacute vs Control 58 13 71 36 7 43
Early Chronic vs Control 34 12 46 25 4 29
Late Chronic vs Control 52 16 68 60 5 65
Reactome
Acute vs Control 315 26 341 257 37 294
Subacute vs Control 146 36 182 71 24 102
Early Chronic vs Control 57 30 87 34 27 61
Late Chronic vs Control 105 61 171 93 23 116