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start [2009/12/30 13:29]
aconesa
start [2010/05/03 16:51] (current)
jcarbonell
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 ====== Serial Expression Analysis ====== ====== Serial Expression Analysis ======
  
-Serial Expression Analysis ​(SEA) is a web site for the analysis of serial gene expression data. Serial data is understood as multifactorial experimental designs where one of the factors is a quantitative variable such as time or treatment dose. The site offers five different methodologies for the identification of genes and functional classes which significant changes across series. +**S**erial **E**xpression **A**nalysis ​(**SEA**) is a web site for the analysis of serial gene expression data. Serial data is understood as multifactorial experimental designs where one of the factors is a quantitative variable such as time or treatment dose. The site offers five different methodologies for the identification of genes and functional classes which significant changes across series. \\
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 +The following table summarizes the main characteristics of the SEA algorithms:​\\
  
 +|**Name**|**Statistical Strategy**|**Selected Features** |**Selection criterion**|
 +|maSigPro|Univariate Regression|Genes| Genes with differential expression profiles|
 +|maSigFun| Univariate Regression| Functional Categories|Functional classes with most genes having correlated differential expression profiles|
 +|ASCA-genes|ANOVA + Multivariate Projection|Genes|Genes that follow major expression trends|
 +|ASCA-functional|ANOVA + Multivariate Projection + GSA|Functional Categories|Functional classes associated to a given expression trend|
 +|PCA-maSigFun|Multivariate Projection + Univariate Regression|Functional Categories| Functional classes with subset of genes  showing correlated differential expression profiles| ​
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