\n
MultiMBM<\/span><\/h2>\nNovel computational strategies for the identification of a multi-omics signature for diagnosis and prognosis in melanoma with brain metastases <\/strong><\/span><\/h3>\nPatients with metastatic melanoma have one of the highest frequencies of brain metastases when compared to patients with other cancers. In addition, they are less responsive to therapies and have the highest morbidity and mortality of melanoma patients. They currently have few clinical options and knowledge about their mechanisms of function is still limited. We need to know more about the progress of this disease, and for this purpose MultiMBM<\/strong> proposes a powerful strategy that reviews, analyses, summarises and validates in a robust way, all the information available in public databases. This will allow us to find direct and reliable clues to help diagnose and treat patients in a more personalised way, taking into account the specific characteristics of each individual.<\/span><\/p>\n
\nPublications<\/strong>:<\/span><\/p>\n\n- Unveiling common transcriptomic features between melanoma brain metastases and neurodegenerative diseases<\/a><\/em>.\u00a0I Soler-S\u00e1ez, A Karz, MR Hidalgo, B G\u00f3mez-Caba\u00f1es, A L\u00f3pez-Cerd\u00e1n, JF Catal\u00e0-Senent, K Prutisto-Chang, NM Eskow, B Izar, T Redmer, S Kumar, MA Davies, M de la Iglesia-Vay\u00e1, E Hernando*<\/sup>, F Garc\u00eda-Garc\u00eda*<\/sup>.\u00a0Journal of Investigative Dermatology<\/strong>\u00a02024 Sep 24<\/em>,\u00a0doi: 10.1016\/j.jid.2024.09.005<\/em><\/span><\/li>\n
- Novel diagnosis- and progression-related microRNA signatures in melanoma<\/em><\/a>. H G\u00f3mez-Mart\u00ednez, B Gomez-Caba\u00f1es, A Lop\u00e9z-Cerdan, E Hernando*, F Garcia-Garcia*.\u00a0<\/strong>bioRxiv<\/em> 2024 Oct 6. doi:<\/span>\u00a0<\/em><\/span>https:\/\/doi.org\/10.1101\/2023.10.20.563284<\/a><\/li>\n<\/ol>\n
Last congress contributions<\/strong>:<\/span><\/span><\/p>\n\n- Melanoma biomarkers identification using novel computational strategies.\u00a0<\/em><\/span>ISCB-SCS 19th Student Council Symposium on July 23rd, 2023. Lyon, France<\/a>.\u00a0\u00a0H G\u00f3mez-Mart\u00ednez, A L\u00f3pez-Cerd\u00e1n,\u00a0 G Ant\u00f3n-Bernat, E Hernando, F Garc\u00eda-Garc\u00eda.<\/span><\/li>\n
- Multi-omic signature for the diagnosis in melanoma brain metastases.\u00a0<\/em><\/span>ISCB-SCS 19th Student Council Symposium on July 23rd, 2023. Lyon, France<\/a>.\u00a0G Ant\u00f3n-Bernat, H G\u00f3mez-Mart\u00ednez, C Perpi\u00f1\u00e1-Cl\u00e9rigues, C Mag\u00e1n,\u00a0 E Hernando, F Garc\u00eda-Garc\u00eda.<\/span><\/li>\n
- Common hallmarks between melanoma brain metastases and Alzheimer\u2019s disease.<\/span>\u00a0<\/em>ISCB-SCS 19th Student Council Symposium on July 23rd, 2023. Lyon, France<\/a>. I Soler-S\u00e1ez, A Karz, A L\u00f3pez-Cerd\u00e1n, JF Catal\u00e0-Senent, G Ant\u00f3n-Bernat, M de la Iglesia-Vay\u00e1, MR Hidalgo, E Hernando, F Garc\u00eda-Garc\u00eda.<\/span><\/li>\n<\/ol>\n
Media:\u00a0<\/span> <\/strong><\/p>\n\n- Melanoma and brain metastases: cutting-edge technologies for more accurate diagnosis and treatment (video)<\/a><\/li>\n<\/ul>\n
Thanks to \u00abAsociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer\u00bb.<\/span><\/p>\n\u00a0<\/p>\n
\nDifNerOmics<\/span><\/h2>\nStudy of sex differences in neurodegenerative diseases with integrative approaches of omics data and biomedical imaging<\/strong><\/span><\/h3>\nThere are important clinical and epidemiological differences between males and females in many neurodegenerative disorders. The high incidence of these diseases in an increasingly ageing population has intensified the interest and need to understand the relevance of sex in their progression and treatment. In this project, we present a novel characterisation of sex differences in neurodegenerative diseases (Alzheimer Disease, Parkinson Disease and multiple sclerosis), through various computational strategies based on omics, medical imaging, drug repurposing and their integration, with the aim of deepening the understanding of the molecular basis of these pathologies.<\/span><\/p>\n![\"\"](\"https:\/\/bioinfo.cipf.es\/cbl\/wp-content\/uploads\/2023\/08\/PlanNacional2021_neuro-300x237.png\")
<\/h3>\n
\u00a0<\/p>\n
\nPublications<\/strong>:<\/span><\/p>\n\n- A Deep Transcriptome Meta-Analysis Reveals Sex Differences in Multiple Sclerosis<\/em><\/a>.<\/em> JF Catal\u00e0-Senent, Z Andreu, MR Hidalgo, I Soler-S\u00e1ez, FJ Roig Molina, N Yanguas-Cas\u00e1s, A Neva-Alejo, A L\u00f3pez-Cerd\u00e1n, , M de la Iglesia-Vay\u00e1, F Garc\u00eda-Garc\u00eda*.\u00a0<\/span><\/span>Neurobiology of Disease<\/strong>, 2023 Apr 5; 181:106113,\u00a0 doi: https:\/\/doi.org\/10.1016\/j.nbd.2023.106113<\/em><\/span><\/li>\n
- Unveiling sex-based differences in Parkinson Disease: a comprehensive meta-analysis of transcriptomic studies<\/em><\/a>. A L\u00f3pez-Cerd\u00e1n, Z Andreu, MR Hidalgo, R Grillo-Risco, JF Catal\u00e0-Senent, I Soler-S\u00e1ez, A Neva-Alejo, F Gordillo, M de la Iglesia Vaya, F Garcia-Garcia*.\u00a0<\/span><\/span>Biology of Sex Differences<\/strong>\u00a0<\/em>2022 Nov 22;13(1):68. doi:\u00a0<\/em>\u00a010.1186\/s13293-022-00477-5<\/em><\/span><\/li>\n
- The role of microRNAs to understand sex-based differences in Alzheimer\u2019s disease<\/em><\/a>. J Llera-Oyola, H Carceller, Z Andreu, MR Hidalgo, I Soler-S\u00e1ez, F Gordillo, B G\u00f3mez-Caba\u00f1es, B Roson, M de la Iglesia-Vay\u00e1, R Mancuso, FR Guerini, A Mizokami, F Garcia-Garcia*.\u00a0<\/span><\/span>Biology of Sex Differences\u00a0<\/strong>2024 Jan 31. doi:\u00a0<\/em><\/span>https:\/\/doi.org\/10.1186\/s13293-024-00588-1<\/a><\/li>\n
- \u00a0An integrated approach to identify sex-specific genes, transcription factors, and pathways in Alzheimer\u2019s disease.<\/a><\/em>\u00a0A L\u00f3pez-Cerd\u00e1n<\/span><\/span>\u2020<\/sup>, Z Andreu\u2020<\/sup>, MR Hidalgo, I Soler-Sa\u00e9z, M de la Iglesia-Vay\u00e1, A Mikozami, FR Guerini, F Garc\u00eda-Garc\u00eda*<\/sup>.\u00a0\u00a0Neurobiology of Disease\u00a0<\/em><\/strong>2024<\/em> Jul\u00a0<\/em>14.<\/em>\u00a0\u00a0doi:\u00a0<\/em><\/span>10.1016\/j.nbd.2024.106605<\/a><\/li>\n
- MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis<\/em><\/a>.\u00a0\u00a0P Malmierca-Merlo, R Sanchez-Garcia, R Grillo-Risco, I Perez-Diez, JF Catal\u00e0-Senent, S Leon, H Gomez-Martinez, M de la Iglesia-Vaya, MR Hidalgo*, F Garcia-Garcia*.\u00a0Biology of Sex Differences\u00a0<\/strong>2024 Aug. <\/strong>doi:\u00a0<\/span>https:\/\/doi.org\/10.1186\/s13293-024-00640-0<\/a><\/em><\/span><\/li>\n
- Unveiling common transcriptomic features between melanoma brain metastases and neurodegenerative diseases<\/em><\/a>.\u00a0I Soler-S\u00e1ez, A Karz, MR Hidalgo, B G\u00f3mez-Caba\u00f1es, A L\u00f3pez-Cerd\u00e1n, JF Catal\u00e0-Senent, K Prutisto-Chang, NM Eskow, B Izar, T Redmer, S Kumar, MA Davies, M de la Iglesia-Vay\u00e1, E Hernando*<\/sup>, F Garc\u00eda-Garc\u00eda*<\/sup>.\u00a0Journal of Investigative Dermatology<\/strong>\u00a02024 Sep 24<\/em>,\u00a0doi: 10.1016\/j.jid.2024.09.005<\/em><\/span><\/li>\n
- The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies<\/a><\/em>.<\/em> H Carceller, MR Hidalgo, MJ Escarti, J Nacher, M Iglesia-Vaya, F Garcia-Garcia*.\u00a0<\/span><\/span>Biology of Sex Differences<\/strong>\u00a02024 Jul 27.\u00a0doi:<\/span>\u00a0<\/em><\/span>10.1186\/s13293-024-00635-x<\/a>\u00a0<\/span><\/li>\n<\/ol>\n
Last congress contributions<\/strong>:<\/span><\/p>\n\n- Characterising sex differences in neurodegenerative diseases using novel functional genomics strategies<\/em>. MR Hidalgo, I Soler-S\u00e1ez, F Gordillo-Gonz\u00e1lez, B G\u00f3mez-Caba\u00f1es, Z Andreu, H Carceller, J Llera-Oyola, B Ros\u00f3n, A L\u00f3pez-Cerd\u00e1n, JF Catal\u00e0-Senent, A Porlan, M Pozo-Morales, R Grillo-Risco, P Malmierca-Merlo, I P\u00e9rez-D\u00edez, R S\u00e1nchez-Garc\u00eda, M de la Iglesia-Vay\u00e1, R Mancuso, FR Guerini, A Mizokami, F Garc\u00eda-Garc\u00eda.<\/span>\u00a0Congreso Interdisciplinar en Gen\u00e9tica Humana. 15-17 de Noviembre 2023, M\u00e1laga, Espa\u00f1a<\/a>.<\/li>\n
- Common hallmarks between melanoma brain metastases and Alzheimer\u2019s disease.\u00a0<\/em><\/span>ISCB-SCS 19th Student Council Symposium on July 23rd, 2023. Lyon, France<\/a>. I Soler-S\u00e1ez, A Karz, A L\u00f3pez-Cerd\u00e1n, JF Catal\u00e0-Senent, G Ant\u00f3n-Bernat, M de la Iglesia-Vay\u00e1, MR Hidalgo, E Hernando, F Garc\u00eda-Garc\u00eda.<\/span><\/li>\n
- Sex differences in Alzheimer\u2019s disease through meta-analysis of single cell studies.<\/span>\u00a0<\/em>ISCB-SCS 19th Student Council Symposium on July 23rd, 2023. Lyon, France<\/a>. B G\u00f3mez-Caba\u00f1es, I Soler-S\u00e1ez, F Gordillo, H Carceller, MR Hidalgo, F Garc\u00eda-Garc\u00eda.<\/span><\/li>\n
- Statistical methodology for functional meta-analysis of sex-based disparities in neurological diseases.<\/em>\u00a0The 10th International Congress on Industrial and Applied Mathematics 20-25 Aug. 2023, Waseda University, Tokyo, Japan.<\/span>\u00a0https:\/\/iciam2023.org<\/a>. MR Hidalgo, F Garcia-Garcia, B Gomez-Caba\u00f1es, C Perpi\u00f1a-Clerigues, I Soler-Saez, F Gordillo, G Anton-Bernat, A L\u00f3pez-Cerdan, R Grillo-Risco, JF Catal\u00e0-Senent.<\/span><\/li>\n
- Molecular and functional atlas of sex-differences in secondary-progressive multiple sclerosis: neurons characterization<\/em>.<\/span>\u00a03rd Women in Bioinformatics & Data Science LA Conference, 20-23 Sep 2022<\/a>. I Soler-S\u00e1ez, Z Andreu, JF Catal\u00e0-Senent, R Grillo-Risco, A L\u00f3pez-Cerd\u00e1n, A Neva-Alejo, B G\u00f3mez-Caba\u00f1es, H Carceller, M de la Iglesia-Vay\u00e1, MR Hidalgo and F Garc\u00eda-Garc\u00eda.<\/span><\/li>\n
- Identifying microRNA biomarkers in Multiple Sclerosis exhibiting a sex-related differential pattern<\/em><\/span>.\u00a03rd Women in Bioinformatics & Data Science LA Conference, 20-23 Sep 2022<\/a>. Ester Mu\u00f1oz del Campo, Jos\u00e9 Francisco Catal\u00e0-Senent and Francisco Garc\u00eda-Garc\u00eda.<\/span><\/li>\n
- Novel integration of single cell transcriptomics studies for the characterization of sex differences in Parkinson disease<\/em>.<\/span>\u00a03rd Women in Bioinformatics & Data Science LA Conference, 20-23 Sep 2022<\/a>. F Gordillo, J Llera Oyola, I Soler-Saez, MR Hidalgo, Z Andreu, M de la Iglesia-Vay\u00e1, H Carceller and F Garc\u00eda Garc\u00eda.<\/span><\/li>\n
- Sex-differences in Alzheimer\u2019s disease: a meta-analysis of microRNA studies<\/span><\/em>.<\/span>\u00a03rd Women in Bioinformatics & Data Science LA Conference, 20-23 Sep 2022<\/a>. J Llera Oyola, Z Andreu, I Soler- S\u00e1ez, F Gordillo, H Carceller, M de la Iglesia Vay\u00e1, MR Hidalgo and F Garc\u00eda Garc\u00eda.<\/span><\/li>\n
- Sex differences in the molecular basis of multiple sclerosis: meta-analysis of transcriptomic data<\/em>.<\/span>\u00a021st European Conference on Computational Biology. 12-21 Sep 2022, Sitges, Barcelona.<\/a>\u00a0JF Catal\u00e0-Senent, Z Andreu, MR Hidalgo, FJ Roig, N Yanguas-Cas\u00e1s, A Neva-Alejo, A L\u00f3pez-Cerd\u00e1n, I Soler-S\u00e1ez, M de la Iglesia-Vay\u00e1, F Garc\u00eda-Garc\u00eda.<\/span><\/li>\n
- Molecular and functional atlas of sex-differences in multiple sclerosis subtypes analising single cell and single nucleus transcriptomic data<\/em>.\u00a0<\/span>21st European Conference on Computational Biology. 12-21 Sep 2022, Sitges, Barcelona.<\/a>\u00a0I Soler-S\u00e1ez, Z Andreu, JF Catal\u00e0-Senent, R Grillo-Risco, A L\u00f3pez-Cerd\u00e1n, A Neva-Alejo, B G\u00f3mez, H Carceller, M de la Iglesia-Vay\u00e1, MR Hidalgo, F Garc\u00eda-Garc\u00eda.<\/span><\/li>\n<\/ol>\n
Media:\u00a0 <\/strong><\/span><\/p>\n\n- DifNerOmics: Novel computational strategies for the study of sex differences in neurodenerative diseases (video)<\/a><\/li>\n<\/ul>\n
This research was supported by and partially funded by the Institute of Health Carlos III (project IMPaCT-Data, exp. IMP\/00019), co-funded by the European Union, European Regional Development Fund (ERDF, \u201cA way to make Europe\u201d), and PID2021-124430OA-I00 funded by MICIU\/AEI\/10.13039\/501100011033\u00a0and by FEDER, UE. Irene Soler-S\u00e1ez thanks the Spanish Ministry of Universities for her predoctoral grant FPU20\/03544<\/span><\/p>\n\u00a0<\/p>\n
\nCellsNer<\/span><\/h2>\nImpact of sex differences in Parkinson’s and Alzheimer’s disease: a single-cell and spatial transcriptomic characterisation for the identification of new biomarkers of diagnosis and progression<\/strong><\/h3>\nThe main objective of this project is the identification and evaluation of novel sex-specific differential gene expression signatures considering cell type and spatial localisation, to improve the diagnosis, treatment and prognosis of patients with Parkinson’s and Alzheimer’s disease. The results of our work will address questions that will be determinant for the elucidation of the molecular mechanisms underlying sexual dimorphism in both diseases.<\/span><\/p>\n![\"\"](\"https:\/\/bioinfo.cipf.es\/cbl\/wp-content\/uploads\/2025\/01\/FigureProposals_englishVersion-1-300x217.png\")
<\/p>\n
\neCAN Plus<\/span><\/h2>\nEnhancing the digital capabilities of cancer centres in the European Union to improve prevention and care<\/h3>\n
➡️ eCAN Plus<\/a><\/span> aims to promote cancer prevention and treatment through digital health solutions \u2013 for the benefit of patients, healthcare professionals and citizens across Europe.<\/span><\/p>\n💡 The purpose of<\/span> eCAN Plus<\/a><\/span> is to create a strong digital ecosystem where cancer patients and healthcare professionals can better navigate and utilize digital technologies for treatment, follow-up and self-care.<\/span><\/p>\n📌 The project involves 83 partners from 23 EU countries \u2013 including regions, hospitals, cancer centres and patient organisations.<\/span><\/p>\n🗓 Project period: May 2025 – April 2029.<\/span><\/p>\n![\"\"](\"https:\/\/bioinfo.cipf.es\/cbl\/wp-content\/uploads\/2025\/02\/1-300x136.png\")
<\/p>\n
This research is supported by EU4H Project Grants. Project number: 101219434.\u00a0<\/span> \u00a0Last\u00a0 posts<\/a>.<\/span><\/p>\n
\n\u00a0<\/h2>\n\n\n
\n","protected":false},"excerpt":{"rendered":"
MultiMBM,\u00a0 DifNerOmics,\u00a0 CellsNer,\u00a0eCAN Plus MultiMBM Novel computational strategies for the identification of a multi-omics signature for diagnosis and prognosis in melanoma with brain metastases Patients with metastatic melanoma have one of the highest frequencies of brain metastases when compared to patients with other cancers. In addition, they are less responsive to therapies and have the…
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Patients with metastatic melanoma have one of the highest frequencies of brain metastases when compared to patients with other cancers. In addition, they are less responsive to therapies and have the highest morbidity and mortality of melanoma patients. They currently have few clinical options and knowledge about their mechanisms of function is still limited. We need to know more about the progress of this disease, and for this purpose MultiMBM<\/strong> proposes a powerful strategy that reviews, analyses, summarises and validates in a robust way, all the information available in public databases. This will allow us to find direct and reliable clues to help diagnose and treat patients in a more personalised way, taking into account the specific characteristics of each individual.<\/span><\/p>\n Publications<\/strong>:<\/span><\/p>\n Last congress contributions<\/strong>:<\/span><\/span><\/p>\n Media:\u00a0<\/span> <\/strong><\/p>\n Thanks to \u00abAsociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer\u00bb.<\/span><\/p>\n \u00a0<\/p>\n There are important clinical and epidemiological differences between males and females in many neurodegenerative disorders. The high incidence of these diseases in an increasingly ageing population has intensified the interest and need to understand the relevance of sex in their progression and treatment. In this project, we present a novel characterisation of sex differences in neurodegenerative diseases (Alzheimer Disease, Parkinson Disease and multiple sclerosis), through various computational strategies based on omics, medical imaging, drug repurposing and their integration, with the aim of deepening the understanding of the molecular basis of these pathologies.<\/span><\/p>\n \u00a0<\/p>\n Publications<\/strong>:<\/span><\/p>\n Last congress contributions<\/strong>:<\/span><\/p>\n Media:\u00a0 <\/strong><\/span><\/p>\n This research was supported by and partially funded by the Institute of Health Carlos III (project IMPaCT-Data, exp. IMP\/00019), co-funded by the European Union, European Regional Development Fund (ERDF, \u201cA way to make Europe\u201d), and PID2021-124430OA-I00 funded by MICIU\/AEI\/10.13039\/501100011033\u00a0and by FEDER, UE. Irene Soler-S\u00e1ez thanks the Spanish Ministry of Universities for her predoctoral grant FPU20\/03544<\/span><\/p>\n \u00a0<\/p>\n The main objective of this project is the identification and evaluation of novel sex-specific differential gene expression signatures considering cell type and spatial localisation, to improve the diagnosis, treatment and prognosis of patients with Parkinson’s and Alzheimer’s disease. The results of our work will address questions that will be determinant for the elucidation of the molecular mechanisms underlying sexual dimorphism in both diseases.<\/span><\/p>\n ➡️ eCAN Plus<\/a><\/span> aims to promote cancer prevention and treatment through digital health solutions \u2013 for the benefit of patients, healthcare professionals and citizens across Europe.<\/span><\/p>\n 💡 The purpose of<\/span> eCAN Plus<\/a><\/span> is to create a strong digital ecosystem where cancer patients and healthcare professionals can better navigate and utilize digital technologies for treatment, follow-up and self-care.<\/span><\/p>\n 📌 The project involves 83 partners from 23 EU countries \u2013 including regions, hospitals, cancer centres and patient organisations.<\/span><\/p>\n 🗓 Project period: May 2025 – April 2029.<\/span><\/p>\n This research is supported by EU4H Project Grants. Project number: 101219434.\u00a0<\/span> \u00a0Last\u00a0 posts<\/a>.<\/span><\/p>\n MultiMBM,\u00a0 DifNerOmics,\u00a0 CellsNer,\u00a0eCAN Plus MultiMBM Novel computational strategies for the identification of a multi-omics signature for diagnosis and prognosis in melanoma with brain metastases Patients with metastatic melanoma have one of the highest frequencies of brain metastases when compared to patients with other cancers. In addition, they are less responsive to therapies and have the…
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\nDifNerOmics<\/span><\/h2>\n
Study of sex differences in neurodegenerative diseases with integrative approaches of omics data and biomedical imaging<\/strong><\/span><\/h3>\n
<\/h3>\n
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\nCellsNer<\/span><\/h2>\n
Impact of sex differences in Parkinson’s and Alzheimer’s disease: a single-cell and spatial transcriptomic characterisation for the identification of new biomarkers of diagnosis and progression<\/strong><\/h3>\n
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\neCAN Plus<\/span><\/h2>\n
Enhancing the digital capabilities of cancer centres in the European Union to improve prevention and care<\/h3>\n
<\/p>\n
\n\u00a0<\/h2>\n\n\n
\n","protected":false},"excerpt":{"rendered":"
Leer m\u00e1s<\/a><\/p>\n","protected":false},"author":2,"featured_media":200,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/pages\/199"}],"collection":[{"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/comments?post=199"}],"version-history":[{"count":72,"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/pages\/199\/revisions"}],"predecessor-version":[{"id":1855,"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/pages\/199\/revisions\/1855"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/media\/200"}],"wp:attachment":[{"href":"https:\/\/bioinfo.cipf.es\/cbl\/wp-json\/wp\/v2\/media?parent=199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}