PATOSS

Authors

Fernando Gordillo-González , Cristina Galiana-Rosello , Irene Soler-Sáez , Borja Gomez-Cabañes , Ruben Grillo-Risco , Maria de la Iglesia-Vaya , Haruhiko Siomi , Mie Kobayashi-Ishihara , Marta R Hidalgo , Francisco García-García .


Affiliations and funding

 

 

 


PATOSS (PArkinson Transcriptomic Overview of Sex-differences at a Single cell resolution) is a web-based tool created by the Computational Biomedicine Lab (CBL) at the CIPF research centre for the study and dissemination of sex differences in Parkinson’s disease. We present in this web resource a variety of user-friendly tools to navigate through the results obtained from integrative sn-RNAseq meta-analyses of PD post-mortem brain samples datasets, both at the coding gene and the transposable element (TE) level.


The integration of coding genes involved two meta-analyses covering different brain regions: one comprising four studies of the substantia nigra pars compacta (SNpc) and another comprising two studies involving cortical samples (CT). In contrast, the integration of TEs was performed only in the four SNpc studies.

For this integration, briefly, we followed a common processing pipeline and annotated the major brain cell types (neurons, oligodendrocytes, microglia, and astrocytes). For each cell type, we performed a sex-specific differential expression analysis and meta-analyzed the results using a random-effects model. For more information on the methods used, please refer to the publications cited in the section below.

Citation

If using some of the results contained in this webtool, please kindly cite its associated papers:

For gene expression: Gordillo-González, F., Soler-Sáez, I., Galiana-Roselló, C., Burmeister, T.-S., Gómez-Cabañes, B., Grillo-Risco, R., Hidalgo, M. R., Romero-Ramos, M., & García-García, F. (2026). Uncovering sex differences in Parkinson’s Disease through metaanalysis of single cell transcriptomic studies (p. 2024.12.20.628852). bioRxiv. https://doi.org/10.1101/2024.12.20.628852

For TE dysregulation: Gordillo-González, F., Galiana-Roselló, C., Grillo-Risco, R., Soler-Saéz, I., Hidalgo, M. R., Siomi, H., Kobayashi-Ishihara, M., & García-García, F. (2026). Transposable elements as new players to decipher sex differences in Parkinson Disease (p. 2026.03.27.714370). bioRxiv. https://doi.org/10.64898/2026.03.27.714370