Sexual selection halts the relaxation of protamine 2 among rodents.

TitleSexual selection halts the relaxation of protamine 2 among rodents.
Publication TypeJournal Article
Year of Publication2011
AuthorsLüke L, Vicens A, Serra F, Luque-Larena JJ, Dopazo H, Roldan ERS, Gomendio M
Journal TitlePloS one
Volume6
Pagese29247
Journal Date2011
ISSN1932-6203
AbstractSexual selection has been proposed as the driving force promoting the rapid evolutionary changes observed in some reproductive genes including protamines. We test this hypothesis in a group of rodents which show marked differences in the intensity of sexual selection. Levels of sperm competition were not associated with the evolutionary rates of protamine 1 but, contrary to expectations, were negatively related to the evolutionary rate of cleaved- and mature-protamine 2. Since both domains were found to be under relaxation, our findings reveal an unforeseen role of sexual selection: to halt the degree of degeneration that proteins within families may experience due to functional redundancy. The degree of relaxation of protamine 2 in this group of rodents is such that in some species it has become dysfunctional and it is not expressed in mature spermatozoa. In contrast, protamine 1 is functionally conserved but shows directed positive selection on specific sites which are functionally relevant such as DNA-anchoring domains and phosphorylation sites. We conclude that in rodents protamine 2 is under relaxation and that sexual selection removes deleterious mutations among species with high levels of sperm competition to maintain the protein functional and the spermatozoa competitive.
URLhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029247
DOI10.1371/journal.pone.0029247
Alternate JournalPLoS ONE