MEPA10 - Molecular Evolution, Phylogenetics and Adaptation


Course description:

More than 30 years ago, Theodosius Dobzhansky claimed:

"Nothing in Biology makes sense except in the light of evolution" Currently, the simplest Bioinformatics analysis uses species comparisons in order to hypothesise the function of a novel biological sequence. Moreover, in most Molecular Biology labs, evolutionary and phylogenetic concepts are constantly being used with more or less formality: homology, similarity, evolutionary rates, long branch attraction, rooted and unrooted trees, monophyletic group, molecular clock, adaptation, lineage effects, neutralism, cladograms, phylograms, etc. The course covers these and other major concepts in Evolutionary Biology and Phylogenetics. Attendees will acquire specific skills in using the methodology in Comparative and Evolutionary Biology problems. The course is designed to be a mixture of theoretical and practical sessions developed in 5 days, where both classic and recently introduced methods for phylogenetic reconstruction will be covered. As outcome of the more recent developments, the course dedicates a day to the analysis of adaptation at a molecular level. The software resources that will be used in the practical sessions include: Phyml, Phylip, MEGA, TreePuzzle, MrBayes, PAML, Modeltest-Protest, and the Phylemon web server.


Visit the GTPB website for details:


Mon, 15/02/2010 (All day) - Fri, 19/02/2010 (All day)
Instituto Gulbenkian de Ciencia (IGC), Oeiras, Portugal