Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity.

TitleUsing activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity.
Publication TypeJournal Article
Year of Publication2015
AuthorsAmadoz A, Sebastian-Leon P, Vidal E, Salavert F, Dopazo J
Journal TitleScientific reports
Volume5
Pages18494
Journal Date2015
ISSN2045-2322
Keywordsbiomarkers, pathways, signalling, Systems biology
AbstractMany complex traits, as drug response, are associated with changes in biological pathways rather than being caused by single gene alterations. Here, a predictive framework is presented in which gene expression data are recoded into activity statuses of signal transduction circuits (sub-pathways within signaling pathways that connect receptor proteins to final effector proteins that trigger cell actions). Such activity values are used as features by a prediction algorithm which can efficiently predict a continuous variable such as the IC50 value. The main advantage of this prediction method is that the features selected by the predictor, the signaling circuits, are themselves rich-informative, mechanism-based biomarkers which provide insight into or drug molecular mechanisms of action (MoA).
URLhttp://www.nature.com/articles/srep18494
DOI10.1038/srep18494
Alternate JournalSci Rep