Models of pathways to gain insight into disease mechanisms and drug mode of action

Precision medicine aims to find better ways of defining diseases by gradually substituting conventional clinical–pathological diagnostic criteria with state-of-the-art molecular profiling methodologies. More precise diagnostic of diseases, based on the description of their molecular mechanisms, will foster the advent of innovative diagnostic, prognostic, and therapeutic strategies precisely tailored to each patient’s requirements. To achieve this, a deeper, systems-based understanding of these disease drivers is required. Here I will discuss how primary gene expression and gene variation data can be integrated and transformed into mechanism-based biomarkers containing higher-level information on disease mechanisms or drug modes of action (MoA) by means of relatively simple models of functional pathways.  

Date: 
Mon, 07/12/2015 (All day)
Place: 
Department of Biosystems Science & Engineering, ETHZ, Basel, Switzerland