Dissecting deleterious mutation complexity. Nature Genetics Reviews highlights our Mol. Syst. Biol. interactome paper

Dissecting deleterious mutation complexity

Nature Reviews genetics highlights our paper "The role of the interactome in the maintenance of deleterious variability in human populations" by Garcia-Alonso et al., recently published in Mol.Syst Biol.

"Deleterious mutations are predicted to disrupt gene function and to reduce organismal fitness. A surprising result from various genome sequencing studies of healthy humans is the high prevalence of deleterious mutations, including mutations that occur in a homozygous state.
Two new studies characterize the burden of deleterious variants in different populations and provide rationale for their tolerance based on protein network topology."

Read more in Nature Review Genetics.