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gene_set_analysis [2012/04/23 18:12]
mbleda
gene_set_analysis [2012/04/23 18:13] (current)
mbleda [FatiScan]
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 **FatiScan** implements a segmentation test which checks for **asymmetrical distributions of regulatory elements** (microRNA and Transcription factors) associated to genes ranked in a list.  **FatiScan** implements a segmentation test which checks for **asymmetrical distributions of regulatory elements** (microRNA and Transcription factors) associated to genes ranked in a list. 
  
-{{:​images:​methods:​fatiscan.png?​170 |FatiScan}}+{{:​images:​methods:​fatiscan.png?​200 |FatiScan}}
  
 Unique in this type of approaches, this test **only** needs the list of **ordered genes** and not the original data which generated the sorting. This means that can be applied to the study of the relationship of regulatory elements to any type of experiment whose outcome is a sorted list of genes. Genes sorted by differential expression between two experimental conditions can be studied, but also genes correlated to a clinical variable (such as the level of a metabolite) or even to survival. Moreover, other lists of genes ranked by any other experimental or theoretical criteria can be studied (e.g. genes arranged by physico-chemical properties, mutability, structural parameters, etc.) in order to understand whether there is any regulatory element which is related to the experimental parameter studied. Unique in this type of approaches, this test **only** needs the list of **ordered genes** and not the original data which generated the sorting. This means that can be applied to the study of the relationship of regulatory elements to any type of experiment whose outcome is a sorted list of genes. Genes sorted by differential expression between two experimental conditions can be studied, but also genes correlated to a clinical variable (such as the level of a metabolite) or even to survival. Moreover, other lists of genes ranked by any other experimental or theoretical criteria can be studied (e.g. genes arranged by physico-chemical properties, mutability, structural parameters, etc.) in order to understand whether there is any regulatory element which is related to the experimental parameter studied.
gene_set_analysis.txt ยท Last modified: 2012/04/23 18:13 by mbleda
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