Work Package 3: Functional Next Generation Sequencing

Objectives

Functional NGS deals with the utilization of high-throughput sequencing to understand different functional aspects of the genomes, from transcriptional activity (RNA-seq), to epigenetics (Methyl- seq), DNA-protein interactions (Chip-seq), etc. These NGS applications have opened new possibilities to explore genome functioning and require appropriate bioinformatics developments for an accurate analysis. Objectives are:

O3.1 Improve knowledge in quality assessment of functional NGS data.

O3.2 Development appropriate statistical methodologies for the analysis of count data.

O3.3 Learn on the utilization of NGS to understand regulatory and interaction mechanisms of the genome.